13 South Carolina Pork Tenderloin Sandwiches Bigger Than The Bun And Packed With Southern Flavor

South Carolina knows how to make a sandwich that leaves you satisfied and smiling. Pork tenderloin sandwiches in the Palmetto State are legendary for their generous portions and bold flavors that capture the essence of Southern cooking.

I’m taking you on a mouthwatering journey through some of the best spots where the pork hangs over the edges and every bite tastes like home.

1. The Smokehouse (Hilton Head)

Smoke and flavor marry perfectly in this Hilton Head barbecue haven that takes pork seriously. Their tenderloin sandwich showcases hours of careful smoking that infuses the meat with rich, complex flavors you can’t replicate any other way.

The portion size is intimidating in the best possible way, challenging you to finish what they’ve masterfully prepared. Every bite reminds you why barbecue is considered an art form in the South.

2. Red’s Ice House

Casual dining gets an upgrade when you order their signature pork tenderloin sandwich that refuses to stay contained. The atmosphere here is laid-back, but the kitchen takes their sandwiches seriously with generous portions and bold seasonings.

You can taste the dedication in every layer, from the perfectly grilled meat to the fresh toppings. It’s the kind of meal that makes you want to loosen your belt and enjoy every single moment.

3. Betty Lou’s Bistro

Bistro dining meets Southern comfort when you order their elevated take on the classic pork tenderloin sandwich. The attention to detail here is remarkable, from the perfectly toasted artisan bun to the carefully selected toppings that enhance every element.

Despite the upscale presentation, the sandwich remains hearty and satisfying with generous portions. It’s proof that you can enjoy refined dining while still getting that authentic Southern sandwich experience.

4. Kenny B’s French Quarter Café

Bringing a touch of New Orleans flair to the classic Southern sandwich, this café knows how to spice things up. Their pork tenderloin gets a Cajun twist that adds excitement without overwhelming the natural flavors of the meat.

The sandwich arrives looking like a work of art, though you won’t hesitate to dive right in. It’s proof that tradition and creativity can coexist beautifully on one plate.

5. Socastee Station

This spot has built a reputation on serving sandwiches that demand your full attention and appetite. Their pork tenderloin version comes loaded with flavor and size that challenges even the hungriest diners to finish.

The meat is cooked to perfection with a beautiful char that adds depth to each bite. Locals swear by this place, and once you try it, you’ll understand why people drive from neighboring towns just to grab one.

6. Beach Break Grille

Ocean breezes and oversized sandwiches make for an unbeatable combination at this coastal gem. Their pork tenderloin sandwich captures the relaxed vibe of beach life while delivering serious flavor that satisfies your hunger after a day in the sun.

The fresh ingredients and generous portions reflect the restaurant’s commitment to quality. You’ll want to order this sandwich every time you visit the coast.

7. Hazel & Hank’s Gourmet Market

Walking into this gourmet market feels like discovering a hidden treasure chest of flavors. Their pork tenderloin sandwich arrives at your table piled high with perfectly seasoned meat that practically spills over the sides.

You’ll find yourself reaching for napkins as the juices drip down, but that’s part of the charm. The combination of quality ingredients and authentic preparation makes every visit memorable and worth the trip.

8. Barn Bites (food truck)

Food trucks have a special way of serving up comfort, and this mobile kitchen nails it every single time. Their pork tenderloin creation is massive, crispy on the outside, and tender where it counts most.

I love how they manage to pack so much flavor into something you can grab on the go. The convenience factor combined with the taste makes this a local favorite that keeps people coming back for more delicious bites.

9. S.B.H. BBQ (Greenville)

Greenville’s barbecue scene gets a boost from this spot that refuses to skimp on portions or quality. Their pork tenderloin sandwich arrives looking almost comically large, with meat cascading over the bun in glorious abundance.

The sauce they use adds a tangy kick that complements rather than masks the smoky pork flavor. It’s messy eating at its finest, and you wouldn’t want it any other way when chasing authentic taste.

10. Lola (Charleston area)

Charleston’s culinary creativity shines through in their modern interpretation of the traditional pork tenderloin sandwich. The kitchen here isn’t afraid to experiment with flavors while respecting the Southern roots that make this dish special.

You’ll find unexpected combinations that somehow work perfectly together, all piled onto a sandwich that’s far too big for the bun. It’s contemporary cooking that still feels like home cooking at heart.

11. Husk (Charleston)

Award-winning chefs bring their expertise to bear on this iconic Southern sandwich with stunning results. Husk’s commitment to heritage ingredients means the pork itself is something special, sourced from local farms and prepared with reverence for tradition.

The sandwich is enormous yet elegant, balancing size with sophistication in a way few restaurants achieve. This is destination dining for serious sandwich lovers who appreciate quality.

12. Dagwood’s Deli & Sports Bar (Surfside/Myrtle Beach area)

Sports and sandwiches go hand in hand at this lively spot where the portions match the energy. Their pork tenderloin sandwich is built for sharing, though you might find yourself too greedy to let anyone else have a bite of this masterpiece.

The casual atmosphere makes it perfect for game day, and the food quality ensures you’ll remember the meal long after the final score. It’s unpretentious eating at its absolute best.

13. Woody’s

Sometimes the best sandwiches come from places that keep things simple and focus on getting the basics perfect. Woody’s does exactly that with a pork tenderloin sandwich that’s all about quality meat, proper seasoning, and generous portions that leave you satisfied.

There’s no fancy presentation here, just honest food served with pride. The sandwich speaks for itself through flavor and size that reflects true Southern hospitality on a plate.